Social Media in Pharma: Should you bother?….Genericpharma

28 06 2014

New Drug Approvals

Social Media in Pharma: Should you bother?

http://links.genericpharma20.mkt6146.com/servlet/MailView?ms=NjY5NjcyNQS2&r=NTEzNjM3NjI3NDgS1&j=NDYyOTA1OTY2S0&mt=2&rj=NDYyOTA1OTY1S0&rt=0

Generic Pharma 2.0
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Barrie, Ontario L4M 1A3

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XenoPort begins phase II trial of XP-23829 in patients with psoriasis

28 06 2014

New Drug Approvals

XP 23829  from Xenoport is an interesting molecule and as on 27 July 2014, I did not find conclusive evidence

See some structures below

Not sure about the structure of XP 23829

OR

Figure US08148414-20120403-C00019Best fit

OR

Figure US08148414-20120403-C00027Not sure?

(N,N-dimethylcarbamoyl)methyl methyl(2E)but-2-ene-1,4-dioate.

OR

Figure imgf000032_0002

I AM NOT SURE ABOUT THIS ONE ALSO????????

As Football worldcup2014 goes on in Brazil

A thought for it is due…………

……………………………………………………

Best fit is probably is as shown below, and there are reasons

(N,N- Diethylcarbamoyl)methyl methyl (2E)but-2-ene-l,4-dioate 

Introduction

(N,​N-​Diethylcarbamoyl)​methyl methyl (2E)​-​but-​2-​ene-​1,​4-​dioate

Figure imgf000024_0002

C11 H17 N O5, mw 243.13

M.p.: 53-56 °C.

1 H NMR (CDCI3, 400 MHz): δ 6.99-6.90 (m, 2H), 4.83 (s, 2H), 3.80 (s, 3H), 3.39 (q, J = 1.1 Hz, 2H), 3.26 (q, J = 7.2 Hz, 2H), 1 .24 (t, J = 7.2 Hz, 3H), 1 .14 (t, J = 7.2 Hz, 3H). MS (ESI): m/z…

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CHINESE MEDICINE-Xuezhikang , A blood lipid regulator

24 11 2013

New Drug Approvals

Xuezhikang

Xuezhikang, the extract of red yeast rice, has been widely used as a Chinese traditional medicine for the therapy of patients with cardiovascular diseases. It contains natural Lovastatin and its homologues, as well as unsaturated fatty acids, flavonoids, plant sterols and other biologically active substances

The product is a world-recognized blood lipid regulator, which is made by extracting from “specially-made red yeast rice”. It combines modern high-tech biotechnology with traditional Chinese medicine, which can safely and effectively regulate blood lipids in a comprehensive way with proven curative effects and reliable safety.

Pharmacological Effects: the product can reduce blood cholesterol, triglycerides, low density lipoprotein cholesterol, improve high density lipoprotein cholesterol, inhibit atherosclerotic plaque formation, and protect vascular endothelial cells; and inhibit lipid deposition in the liver. The large-scale evidence-based research has proven that long-term use of XUEZHIKANG can greatly reduce the risk of CHD occurrence and decrease the mortality. XUEZHIKANG…

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Zucapsaicin (Zuacta)

24 11 2013

New Drug Approvals

Chemical structure of zucapsaicin

Zucapsaicin (Zuacta), cas 25775-90-0

Chemical name: (Z)-8-methyl-N-vanillyl-6-nonenamide
Molecular formula: C18H27NO3
Molecular mass: 305.41

E merck

Civamide, cis-Capsaicin,

Civanex (zucapsaicin) cream is a TRPV-1 modulator in development for the treatment of signs and symptoms of osteoarthritis of the knee.
Zucapsaicin, the cis-isomer of the natural product capsaicin, is a
topical analgesic that was initially developed by Winston Pharmaceuticals
and approved in Canada in July 2010 for the treatment of
severe pain in adults with osteoarthritis of the knee.

Bronson, J.; Dhar, M.; Ewing, W.; Lonberg, N. In Annual Reports in MedicinalChemistry; John, E. M., Ed.; Academic Press, 2011; Vol. 46, p 433.

The advantagesof zucapsaicin compared with naturally-occurring capsaicin, are reported to be a lesser degree of local irritation (stinging, burning,

erythema) in patients and a greater degree of efficacy in preclinical
animal models of pain.

Bernstein, J. E. U.S. 5063060, 1991.
Bernstein, J. E. U.S. 20050084520 A1, 2005.

The analgesic action…

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EYLEA® (aflibercept) Injection Approved For The Treatment of Macular Edema Following Central Retinal Vein Occlusion In Japan

24 11 2013

New Drug Approvals

TARRYTOWN, N.Y., Nov. 22, 2013 /PRNewswire/ — Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that EYLEA® (aflibercept) Injection has received approval for the treatment of Macular Edema Following Central Retinal Vein Occlusion (CRVO) from the Japanese Ministry of Health, Labour and Welfare.http://www.pharmalive.com/japan-approves-eylea

In November 2011 the United States Food and Drug Administration approved aflibercept for the treatment of wet macular degeneration.

On August 3, 2012 the United States Food and Drug Administration approved Zaltrap (ziv-aflibercept) for use in combination with 5-fluorouracil, leucovorin and irinotecan to treat adults with metastatic colorectal cancer that is resistant to or has progressed following an oxaliplatin‑containing regimen.

In November 2012 the European Medicines Agency (EMA) approved aflibercept for the treatment of wet macular degeneration.

On February 1, 2013 the European Commission granted a marketing authorisation valid throughout the European Union for treatment of adults with metastatic colorectal cancer for whom treatment based on oxaliplatin…

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Lorcaserin…Eisai Expands Marketing and Supply Agreement for Anti-obesity Agent Lorcaserin to Include Most Countries Worldwide

13 11 2013

New Drug Approvals

(1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Eisai Expands Marketing and Supply Agreement for Anti-obesity Agent Lorcaserin to Include Most Countries Worldwide

HATFIELD, England, November 8, 2013 /PRNewswire/ —

Eisai announces today that it has expanded the marketing and supply agreement between its U.S. subsidiary Eisai Inc. and U.S-based Arena Pharmaceuticals Inc.’s Swiss subsidiary, Arena Pharmaceuticals GmbH, for the anti-obesity agent lorcaserin hydrochloride (lorcaserin) (U.S. brand name: BELVIQ®). Whilst the existing agreement granted Eisai Inc. exclusive rights to market and distribute lorcaserin in 21 countries throughout the Americas, the expanded agreement now includes most countries and territories worldwide, most notably, the member states of the European Union, Japan and China (but excludes South Korea, Taiwan, Australia, New Zealand and Israel).http://www.pharmalive.com/eisai-expands-lorcaserin-marketing-and-supply-agreement

Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity…

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Quetiapine

13 11 2013

New Drug Approvals

Quetiapine, astrazeneca

111974-69-7 cas

US 5,948,437*PED,   NDA 022047   Appr may 17 2007 sustained release  formulation

NDA 020639 approved 26.9.1997

patent          approved   expiry

United States 5948437 1997-11-28 2017-11-28
United States 4879288 1994-09-26 2011-09-26
Canada 2251944 2007-04-10 2017-05-27
United States 4879288 1994-09-26 2011-09-26

Quetiapine (/kwɨˈt.əpn/ kwi-ty-ə-peen) (branded as SeroquelXeroquelKetipinor) is a short-acting atypical antipsychotic approved for the treatment of schizophreniabipolar disorder, and along with an antidepressant to treat major depressive disorder.

Annual sales are approximately $5.7 billion worldwide, with $2.9 billion in the United States. The U.S. patent, which  expiredv in 2011, received a pediatric exclusivity extension which pushed its expiration to March 26, 2012.The patent has already expired in Canada. Quetiapine was developed by AstraZeneca from 1992-1996 as an improvement…

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Green Chemistry @ MUN

Less solvent, Less waste, Less energy

Inspiring Science

Casting light on great ideas

Your mom is like science?

Practical scientific analogy education and outreach

DRUG REGULATORY AFFAIRS INTERNATIONAL

Drug Regulatory affairs by DR ANTHONY MELVIN CRASTO, Worlddrugtracker

Syntheticnature

Total Synthesis and general organic chemistry

pharmupdates.wordpress.com/

News and articles on the Pharmaceutical Industry

Combinatorics and more

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Organic chemistry teaching

Just another WordPress.com weblog

Seven Spheres

Aqua Terra Ignis et Aer

The Molecular Circus

How molecules make the world go round

Chemtips

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The Heterocyclist

A blog about heterocyclic chemistry

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Green Chemistry @ MUN

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Inspiring Science

Casting light on great ideas

Your mom is like science?

Practical scientific analogy education and outreach

DRUG REGULATORY AFFAIRS INTERNATIONAL

Drug Regulatory affairs by DR ANTHONY MELVIN CRASTO, Worlddrugtracker

Syntheticnature

Total Synthesis and general organic chemistry

pharmupdates.wordpress.com/

News and articles on the Pharmaceutical Industry

Combinatorics and more

Gil Kalai's blog

Organic chemistry teaching

Just another WordPress.com weblog

Seven Spheres

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The Molecular Circus

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Earth mY homE

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