Mavoglurant (AFQ-056) is an experimental drug candidate for the treatment of fragile X syndrome

27 07 2013

New Drug Approvals

マボグルラントFile:Mavoglurant.svg

ماووگلوران

Mavoglurant (AFQ-056) is an experimental drug candidate for the treatment of fragile X syndrome.[1] It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGLU5).[2]

Mavoglurant is under development by Novartis and is currently in Phase II and Phase III clinical trials.[1][3] If successful, it would be the first drug to treat the underlying disorder instead of the symptoms of fragile X syndrome.[4]

 

  1. P. Cole (2012). “Mavoglurant”. Drugs of the Future37 (1): 7–12. doi:10.1358/dof.2012.37.1.1772147. 
  2. Levenga, J; Hayashi, S; De Vrij, FM; Koekkoek, SK; Van Der Linde, HC; Nieuwenhuizen, I; Song, C; Buijsen, RA et al. (2011). “AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome”. Neurobiology of disease42 (3): 311–7. doi:10.1016/j.nbd.2011.01.022. PMID 21316452. 
  3.  Jacquemont…

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Curis phase 1 Cancer Trial for CUDC-427 Begins

27 07 2013

New Drug Approvals

CUDC-427, GDC-0917; RG-7459

Genentech Inc (Roche Holding AG)

Curis licenses GDC-0917 from Genentech

Curis Cancer Trial Begins
Curis Inc. has initiated patient dosing in a second Phase 1 dose-escalation study of CUDC-427 that is being conducted using a continuous, twice-daily oral dosing regimen in patients with advanced and refractory solid tumors or lymphoma.

FULL STORY

http://www.dddmag.com/news/2013/07/curis-cancer-trial-begins?et_cid=3387991&et_rid=523035093&type=headline

About CUDC-427 (GDC-0917)

CUDC-427 is an orally bioavailable small molecule that is designed to promote cancer cell death by antagonizing IAP proteins.  IAP proteins are a family of functionally and structurally related proteins that promote cancer cell survival by inhibiting programmed cell death, also known as apoptosis, which is a normal process inherent in every cell.  Using IAP proteins and other anti-apoptotic factors, cancer cells evade apoptosis in response to a variety of signals, including those provided by anti-cancer agents such as chemotherapy, or naturally occurring inflammatory and immune signals transmitted through members of the…

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Antibody Effective Against Norovirus

27 07 2013

New Drug Approvals

 

Antibody Effective Against Norovirus
Researchers have released data showing that a monoclonal antibody can neutralize human norovirus. Norovirus causes roughly 20 million cases of acute diarrhea and vomiting annually in the United States, alone. It is also responsible for roughly 800 deaths annually.

FULL STORY

http://www.dddmag.com/news/2013/07/antibody-effective-against-norovirus?et_cid=3387991&et_rid=523035093&type=headline

 

What is Norovirus?

Norovirus is a stomach bug that sets in within 10 hours of transmission and usually lasts up to three days. It is completely different from the flu in that only your stomach is affected. While most people recover completely after three days, norovirus is more serious for young children, the elderly and people with other serious health conditions. Every year 70,000 people are hospitalized and 800 deaths are caused by the virus.

What are the symptoms?

The most common symptoms of norovirus include stomach pain, vomiting, diarrhea and nausea. Some people also experience a low-grade fever, headache and body…

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CSIR, INDIA-WO PATENT–synthesis of amprenavir and saquinavir

27 07 2013

New Drug Approvals

amprenavir

saquinavir

A process for synthesis of syn azido epoxide and its use as intermediate in the synthesis of amprenavir and saquinavir
Published as ———WO-2013105118
Council of Scientific & Industrial Research

http://worldwide.espacenet.com:80/publicationDetails/biblio?CC=WO&NR=2013105118A1&KC=A1&FT=D&DB=EPODOC&locale=en_EP&date=20130718&rss=true

Inventors

Gadakh, Sunita, Khanderao; Rekula, Reddy, Santhosh; Sudalai, Arumugam
Publication date 18-JUL-2013

HIV protease inhibitor

Disclosed herein is a novel route of synthesis of syn azide epoxide of formu 5, which is used as a common intermdeiate for asymmetric synthesis of HIV protease inhibitors such as Amprenavir, Fosamprenavir, Saquinavir and formal synthesis of Darunavir and Palinavir obtained by Cobalt- catalyzed hydrolyti kinetic resolution of racemic anti-(2SR, 3SR) – 3 -azido – 4 -phenyl – 1, 2- epoxybutane (azido-epoxide

IN2012DE82 10-JAN-2012 [priority]

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Nanomagnets clean blood

27 07 2013

New Drug Approvals

Nanomagnets clean blood

Nanoparticles latch onto toxins in blood but are magnetically trapped before they can enter the body

http://www.rsc.org/chemistryworld/2013/07/nanomagnets-clean-blood

The group used their extracorporeal circuit to remove lead and the drug digoxin from the blood of rats. Target compounds in blood adhered to the nanoparticles as they collided within the circuit. The nanoparticles were then collected by magnetic separation with the toxin immobilised on the particle surface before blood could re-enter the body.

Cleaning cadmium from blood
The nanocomposite binds to cadmium ions in the blood and a magnet is used to attract the resulting complex for removal
Removal of cadmium ions from a human blood sample with a magnet

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Biosimilars applications under review by EMA – 2013 Q2

27 07 2013

New Drug Approvals

The European Medicines Agency (EMA) is the body responsible for approval of biosimilars within the EU. A legal framework for approving biosimilars was established in 2003. Approval of biosimilars is based on an abbreviated registration process, which allows biosimilars manufacturers to provide a reduced package of information compared to originator drugs, provided they can prove ‘similarity’ to the originator or ‘reference drug’.

read all at

http://www.gabionline.net/Biosimilars/General/Biosimilars-applications-under-review-by-EMA-2013-Q2

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First biosimilar filgrastims launched in Japan

27 07 2013

New Drug Approvals

International nonproprietary name: Filgrastim

 Chemical name: N-L- Methionyl colony-stimulating factor (human genetically engineered); non-glycated protein consisted of 175 amino acids.

Chemical name: N-L- Methionyl colony-stimulating factor (human genetically engineered); non-glycated protein consisted of 175 amino acids.

Filgrastim is a granulocyte colony-stimulating factor (G-CSF) analog used to stimulate the proliferation and differentiation of granulocytes.[1] It is produced by recombinant DNA technology. The gene for human granulocyte colony-stimulating factor is inserted into the genetic material of Escherichia coli. The G-CSF then produced by E. coli is different from G-CSF naturally made in humans.

Hematopoietic growth factor. Interacting with receptors on the surface of hematopoietic cells it regulates production and release of neutrophils from the bone marrow to the peripheral blood. Dose dependant number growth of neutrophils with normal or increased functional activity is passing for 24 hours.

Filgrastim is marketed under several brand names, including Neupogen (

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Green Chemistry @ MUN

Less solvent, Less waste, Less energy

Inspiring Science

Casting light on great ideas

Your mom is like science?

Practical scientific analogy education and outreach

DRUG REGULATORY AFFAIRS INTERNATIONAL

Drug Regulatory affairs by DR ANTHONY MELVIN CRASTO, Worlddrugtracker

Syntheticnature

Total Synthesis and general organic chemistry

pharmupdates.wordpress.com/

News and articles on the Pharmaceutical Industry

Combinatorics and more

Gil Kalai's blog

Organic chemistry teaching

Just another WordPress.com weblog

Seven Spheres

Aqua Terra Ignis et Aer

The Molecular Circus

How molecules make the world go round

Chemtips

Because Organic Chemistry is Hard Enough

The Heterocyclist

A blog about heterocyclic chemistry

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Experience Culture, Physical Activity and Nature on Every Trip

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a chronicle of our nomadic wanderings

Green Chemistry @ MUN

Less solvent, Less waste, Less energy

Inspiring Science

Casting light on great ideas

Your mom is like science?

Practical scientific analogy education and outreach

DRUG REGULATORY AFFAIRS INTERNATIONAL

Drug Regulatory affairs by DR ANTHONY MELVIN CRASTO, Worlddrugtracker

Syntheticnature

Total Synthesis and general organic chemistry

pharmupdates.wordpress.com/

News and articles on the Pharmaceutical Industry

Combinatorics and more

Gil Kalai's blog

Organic chemistry teaching

Just another WordPress.com weblog

Seven Spheres

Aqua Terra Ignis et Aer

The Molecular Circus

How molecules make the world go round

Chemtips

Because Organic Chemistry is Hard Enough

The Heterocyclist

A blog about heterocyclic chemistry

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Travelling Stories & Photographs From One Travel Lover To Another

The Sacred Lives of Objects

Seeing and Being Seen in the Modern Museum

Earth mY homE

Seeing the Surroundings

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Tibet, Human Rights, Injustice, Animal Abuse, Child Abuse

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