OPRD PAPER-An Improved Manufacturing Process for the Antimalaria Drug artemether

6 06 2013

New Drug Approvals

Abstract Image

Novartis Pharma AG, Chemical and Analytical Development and Chemical Operations, CH-4002 Basel, Switzerland.
Org. Process Res. Dev., 2007, 11 (3), pp 336–340
DOI: 10.1021/op0602425
Artemisinin and its derivatives, such as artemether, are highly sensitive compounds, which require careful optimized production processes for their manufacture. Due to robustness issues, the manufacturing procedure of the reduction of artemisinin with potassium borohydride to dihydroartemisinin was reinvestigated. The most important factor for obtaining optimal yields is to ensure low levels of contamination of potassium hydroxide in potassium borohydride. Application of a lower reaction temperature, fast addition rate of potassium borohydride, and careful control of the pH during the quench with acid are further important parameters in guaranteeing a robust process. In the redesign of the conversion of dihydroartemisinin to artemether, the yield was increased, and dichloromethane was replaced by the ecologically…

View original post 25 more words

Advertisements

Actions

Information

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s




Green Chemistry @ MUN

Less solvent, Less waste, Less energy

Inspiring Science

Casting light on great ideas

Your mom is like science?

Practical scientific analogy education and outreach

DRUG REGULATORY AFFAIRS INTERNATIONAL

Drug Regulatory affairs by DR ANTHONY MELVIN CRASTO, Worlddrugtracker

Syntheticnature

Total Synthesis and general organic chemistry

pharmupdates.wordpress.com/

News and articles on the Pharmaceutical Industry

Combinatorics and more

Gil Kalai's blog

Organic chemistry teaching

Just another WordPress.com weblog

Seven Spheres

Aqua Terra Ignis et Aer

The Molecular Circus

How molecules make the world go round

Chemtips

Because Organic Chemistry is Hard Enough

The Heterocyclist

A blog about heterocyclic chemistry

travellingbeets

Travelling Stories & Photographs From One Travel Lover To Another

The Sacred Lives of Objects

Seeing and Being Seen in the Modern Museum

Earth mY homE

Seeing the Surroundings

One Person, One World.

Tibet, Human Rights, Injustice, Animal Abuse, Child Abuse

France Outdoors

Experience Culture, Physical Activity and Nature on Every Trip

Grind Your Wheat

a chronicle of our nomadic wanderings

Green Chemistry @ MUN

Less solvent, Less waste, Less energy

Inspiring Science

Casting light on great ideas

Your mom is like science?

Practical scientific analogy education and outreach

DRUG REGULATORY AFFAIRS INTERNATIONAL

Drug Regulatory affairs by DR ANTHONY MELVIN CRASTO, Worlddrugtracker

Syntheticnature

Total Synthesis and general organic chemistry

pharmupdates.wordpress.com/

News and articles on the Pharmaceutical Industry

Combinatorics and more

Gil Kalai's blog

Organic chemistry teaching

Just another WordPress.com weblog

Seven Spheres

Aqua Terra Ignis et Aer

The Molecular Circus

How molecules make the world go round

Chemtips

Because Organic Chemistry is Hard Enough

The Heterocyclist

A blog about heterocyclic chemistry

travellingbeets

Travelling Stories & Photographs From One Travel Lover To Another

The Sacred Lives of Objects

Seeing and Being Seen in the Modern Museum

Earth mY homE

Seeing the Surroundings

One Person, One World.

Tibet, Human Rights, Injustice, Animal Abuse, Child Abuse

France Outdoors

Experience Culture, Physical Activity and Nature on Every Trip

Grind Your Wheat

a chronicle of our nomadic wanderings

Green Chemistry @ MUN

Less solvent, Less waste, Less energy

Inspiring Science

Casting light on great ideas

Your mom is like science?

Practical scientific analogy education and outreach

DRUG REGULATORY AFFAIRS INTERNATIONAL

Drug Regulatory affairs by DR ANTHONY MELVIN CRASTO, Worlddrugtracker

Syntheticnature

Total Synthesis and general organic chemistry

pharmupdates.wordpress.com/

News and articles on the Pharmaceutical Industry

Combinatorics and more

Gil Kalai's blog

Organic chemistry teaching

Just another WordPress.com weblog

Seven Spheres

Aqua Terra Ignis et Aer

The Molecular Circus

How molecules make the world go round

Chemtips

Because Organic Chemistry is Hard Enough

The Heterocyclist

A blog about heterocyclic chemistry

travellingbeets

Travelling Stories & Photographs From One Travel Lover To Another

The Sacred Lives of Objects

Seeing and Being Seen in the Modern Museum

Earth mY homE

Seeing the Surroundings

One Person, One World.

Tibet, Human Rights, Injustice, Animal Abuse, Child Abuse

France Outdoors

Experience Culture, Physical Activity and Nature on Every Trip

Grind Your Wheat

a chronicle of our nomadic wanderings

%d bloggers like this: